American journal of clinical and experimental immunology | |
Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive? | |
Song Guo Zheng1  | |
关键词: T helper cells; Th1; Th2; Th9; Th17; Tfh; Foxp3+ regulatory T cells; cytokine; differentiation; autoimmunity; | |
DOI : | |
学科分类:过敏症与临床免疫学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3+ regulatory T cells depending upon the presence of other cytokines. IL-6 promotes Th17, but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. Here an update of T cell differentiation and conversion, as well as underlying mechanisms are given.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912140862447ZK.pdf | 796KB | download |