Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?

American journal of clinical and experimental immunology

Song Guo Zheng¹ 

关键词: T helper cells;    Th1;    Th2;    Th9;    Th17;    Tfh;    Foxp3+ regulatory T cells;    cytokine;    differentiation;    autoimmunity;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3+ regulatory T cells depending upon the presence of other cytokines. IL-6 promotes Th17, but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. Here an update of T cell differentiation and conversion, as well as underlying mechanisms are given.

【 授权许可】

CC BY-NC