Elevated Serum Interleukin-23 and Interleukin-6 Levels in Schizophrenic Patients Compared to Those in Healthy Controls

lranian journal of Clinical Infectious Diseases

Mohsen Kianpour⁴  Roodabe Sarabandi¹  Ali Shahraki³  Zahra Zakeri² 

[1] Department of Biology, Isfahan Payame Noor University, Isfahan, IR Iran;Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran;Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, IR Iran;Department of Neurology, Zahedan University of Medical Sciences, Zahedan, IR Iran

关键词: Schizophrenia;    Immune System;    Interleukin-6;    Interleukin-23;   

DOI  :  10.17795/semj38984

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Variousfactors,includinggenetic,psychological,environmental,andimmunedysfunction,maycontributetosusceptibilitytoschizophrenia.Duetoseveralreportsregardingabnormalcytokineproduction,abnormalcytokineconcentrationsandtheirreceptorsinperipheralbloodandcerebrospinalfluid,activationoftheinflammatoryresponsesystem,andalteredlevelsofdifferentcytokinesinacuteschizophreniahavebeenstudiedinrecentyears.Objectives:Thepurposeofthisstudywastoexamineinterleukin-6(IL-6)andIL-23levelsinschizophrenicpatientsversusthoseofhealthycontrols.PatientsandMethods:Inthiscase–controlstudy,serumlevelsofIL-6andIL-23of30schizophrenicpatientsand20age-andgender-matchedhealthycontrolsweremeasuredusinganenzyme-linkedimmunosorbentassay(ELISA).Theserumlevelsofthesecytokinesweremeasuredinschizophrenicpatientsexperiencingtheirfirstepisodewhohadnottakenanypsychoticdrugsforatleast2monthspriortothestudy.StatisticalanalysiswasperformedusingSPSSsoftware,version17.ILlevelsshowedanon-Gaussiandistribution.Thestatisticalanalysiswasperformedusingappropriatestatisticaltests,includingtheKruskal-WallisorMann–Whitneytest.Results:SerumIL-23levelsofschizophrenicpatientsweresignificantlyhigher(696±132pg/mL)thanthoseofthecontrolsubjects(313±33pg/mL)(P=0.007).SerumIL-6levelsoftheschizophrenicpatientswerealsosignificantlyhigherthanthoseofthecontrols(5.28±1.1and2.54±0.32pg/mL,respectively;P=0.01).Conclusions:Thesefindingsindicatethatimmunesystemactivationmightbeinvolvedinthepathophysiologyofschizophrenia.

【 授权许可】

Unknown