Serum and 24-Hour Urinary Uric Acid Levels in Patients with Urolithiasis

lranian journal of Clinical Infectious Diseases

Amid Yazdani¹  Mohammad Yazdani²  Shahzad Baradaran³  Mahmoud Kabiri²  Hamid Nasri⁴  Kourosh Noori-Mahdavi² 

[1] Faculty of Medicine, Isfahan University of Medical sciences, Isfahan, IR Iran;Department of Urology, Isfahan University of Medical sciences, Isfahan, IR Iran;Department of Pathology, Jahad Daneshgahi, University of Isfahan, Isfahan, IR Iran;Department of Nephrology, Isfahan University of Medical sciences, Isfahan, IR

关键词: Uric Acid;    Urolithiasis;    Kidney;   

DOI  :  10.17795/semj26470

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Renalstonediseaseisacommonurologicdisorderaffectingalargenumberofpatientsaroundtheworld.Riskfactorslikeanatomicalabnormalitiesandgeneticmetabolicenvironmentalanddietaryparametershaveimportantrolesinurinarystoneformation.Oneofitsmetabolicparametersisuricacid.Objectives:Theaimofthisstudywastoevaluatethelevelofuricacidinserumand24-hoururinesamplesofpatientswithurolithiasisandcomparethemwithhealthygeneralpopulation.MaterialsandMethods:Thiswasacase-controlstudyperformedintheurologyclinicofNoorhospital,affiliatedtoIsfahanUniversityofMedicalSciences,betweenFebruary2009andJuly2010.Patientsdiagnosedwithurolithiasiswereenrolledasthecasegroup.Healthysubjectsfromthegeneralpopulationwererecruitedasthecontrolgroup.Thepatientswerereferredtothelaboratoryforcheckingtheserumand24hoururinaryuricacidlevels.Results:Fortyfivepatientswithrenalstoneand90healthycontrolswereenrolled.Thelevelofserumuricacidwassignificantlyhigheramongthepatients(P=0.003)andmalepatientshaddramaticallyhigherlevelsthanfemales(P=0.002);but,theurinaryuricacidlevelswerenotsignificantlydifferentbetweenthecasesandthecontrolsorthemalesandthefemales.Conclusions:Serumuricacidlevelmaybeusefulinthescreeningofrenalstones,especiallyinpatientswithapositivehistoryofthisdisease.

【 授权许可】

Unknown