A Comparative Study on Atorvastatin Versus Methotrexate in Rheumatoid Arthritis in a Double Blind Placebo Control Trial.

lranian journal of Clinical Infectious Diseases

AR Dashipour¹  M Sandooghi⁴  Z Zakeri²  S Almasy³ 

[1] MSc in Nutrition , Zahedan University of Medical Sciences, Zahedan, Iran.;Associate Professor, Section of Rheumatology, Department of In-ternal Medicine, Ali-Ebn-Abitaleb Hospital, Zahedan University of Medical Sciences, Za-hedan, Iran,;Assistant Professor, Section of Rheumatology, Department of Internal Medicine, Firoozgar Hospital, Tehran University of Medical Sciences, Tehran, Iran,;Assistant Professor,

关键词: Rheumatoid arthritis;    Atorvastatin;    Methotrexate;    Disease activity score;   

DOI  :  10.17795/semj20458

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background::Thetherapeuticeffectsofmethotrexate(MTX)arewell-knowninrheumatoidarthritis(RA).Also,antiinflammatoryeffectsofatorvastatinhavealreadybeenreported,butnostudyhascomparedtheeffectsofthesetwodrugsonRA.ThereforewedesignedthisstudytocomparetheeffectsofthesedrugsonpatientswithactiveRA.Method::Thestudywasconductedon54patientswithactiveRAwhohadbeenundergoingDisease–Modifying-AntiRheumatic-Drugstherapyforatleast3monthsthatincluded7.5mgmethotrexateweekly.Theywereallocatedintotwogroups.Inadditiontothe7.5mgofMTX,onegroupreceivedanother7.5mgofMTXweeklyandplacebodailyandtheothergroupreceivedatorvastatin40mgdailyandplaceboweekly.Theywerefollowedupfor12weeks.Someclinicalaspectsandthediseaseactivityscore(DAS)wereevaluatedatthebeginningofthestudyandthenattheweeksof6thand12th.Results::Aftermultiplecomparisonsbyrepeatedmeasures,diseaseactivityscoreandothervariablesshowedasignificantreductioninbothgroupsat12thweekaftertreatment;however,theeffectofbothinterventionswassimilarinchangeofDASandothervariablesexceptfordurationofmorningstiffness,thatitdecreasedmoreinstatinthanMTXgroup.Nosignificantsideeffectscausingtoexcludethepatientsfromthestudywereobservedinanyofthetwogroups.Conclusion::weconcludedthatstatin,canserveanimportantroleintreatmentofRA.

【 授权许可】

Unknown