The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28)

Clinical and Experimental Rheumatology

Piet L.C.M. van Riel¹ 

关键词: Rheumatoid arthritis;    disease activity score;    DAS;    DAS28;    Disease activity score;    rheumatoid arthritis;    DAS;    DAS28;   

DOI  :  

学科分类：医学（综合）

来源: Pacini Editore SpA

【 摘 要 】

In rheumatoid arthritis, disease activity cannot be measured using a single variable. The Disease Activity Score (DAS) has been developed as a quantitative index to be able to measure, study and manage disease activity in RA in daily clinical practice, clinical trials, and long term observational studies. The DAS is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and patient self-report of general health. Cut points were developed to classify patients in remission, as well as low, moderate, and severe disease activity in the 1990s. DAS-based EULAR response criteria were primarily developed to be used in clinical trials to classify individual patients as non-, moderate, or good responders, depending on the magnitude of change and absolute level of disease activity at the conclusion of the test.

【 授权许可】

Unknown