Effect of Measles Virus Antibodies from Breast Milk of Nursing Mothers on Seroconversion of Children After Measles Vaccination

lranian journal of Clinical Infectious Diseases

FD Adu³  NCD Ukwandu³  OO Omotade²  OPG Nmorsi¹  CF Odoemele³ 

[1] Department of Virology, College of Medicine University, College Hospital, PMB 5116, Ibadan, Nigeria. Department of Zoology, Faculty of Natural Sciences, Ambrose Alli University, PMB 14 Ekpoma, Nigeria;Institute of Child Health, University College Hospital, Ibadan, Nigeria.;Department of Virology, College of Medicine University, College Hospital, PMB 5116, Ibadan, Nigeria.

关键词: Measles;    Antibodies;    Seroconversion;    Vaccination;   

DOI  :  10.17795/semj20380

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Theeffectsofmeaslesvirus(MV)antibodies(abs)intheseraandbreastmilkofnursingandlactatingmothersonsericonversiontomeaslesvaccinationwasstudied.ThreehundredandnintysixsampleswerecollectedeachfromseraandbreastmilkofnursingmothersandcorrespondingnumberoffingerprickprevaccinationserasamplesonfilterpaperfromtheirchildrenweretestedforMVabs.Eighty(20.2%)mothershadmeasleshaemagglutinationinhibition(HI)absintheirseraand88(27.2%)hadMVHIabsintheirbreastmilk.Eight(2.0%)ofthechildrenwhohadprevaccinationMVabsintheirserawereallfromMVabnegativemothers.Forty-four(37.0%)whocamebackforpostvaccinationseraseroconvertedwhile76(63.3%)gavealowseroconversionrateof37.0%.ResultsshowedthatMVabsineitherseraorbreastmilkofmothersdidnotinterferwithMVvaccinationintheirchildren.Thelowseroconversionrateobtainedwasduetolowvaccinepotencywithtitersrangingbetween(log10-1.0–log10-2.5)TCID/perdose.Thiswasbesideothernon-specificantiviralsubstancesexhibitedvirusneutralizingactivity.

【 授权许可】

Unknown