期刊论文详细信息
lranian journal of Clinical Infectious Diseases
Effect of Measles Virus Antibodies from Breast Milk of Nursing Mothers on Seroconversion of Children After Measles Vaccination
FD Adu3  NCD Ukwandu3  OO Omotade2  OPG Nmorsi1  CF Odoemele3 
[1] Department of Virology, College of Medicine University, College Hospital, PMB 5116, Ibadan, Nigeria. Department of Zoology, Faculty of Natural Sciences, Ambrose Alli University, PMB 14 Ekpoma, Nigeria;Institute of Child Health, University College Hospital, Ibadan, Nigeria.;Department of Virology, College of Medicine University, College Hospital, PMB 5116, Ibadan, Nigeria.
关键词: Measles;    Antibodies;    Seroconversion;    Vaccination;   
DOI  :  10.17795/semj20380
学科分类:基础医学
来源: Shiraz University of Medical Sciences
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【 摘 要 】

Theeffectsofmeaslesvirus(MV)antibodies(abs)intheseraandbreastmilkofnursingandlactatingmothersonsericonversiontomeaslesvaccinationwasstudied.ThreehundredandnintysixsampleswerecollectedeachfromseraandbreastmilkofnursingmothersandcorrespondingnumberoffingerprickprevaccinationserasamplesonfilterpaperfromtheirchildrenweretestedforMVabs.Eighty(20.2%)mothershadmeasleshaemagglutinationinhibition(HI)absintheirseraand88(27.2%)hadMVHIabsintheirbreastmilk.Eight(2.0%)ofthechildrenwhohadprevaccinationMVabsintheirserawereallfromMVabnegativemothers.Forty-four(37.0%)whocamebackforpostvaccinationseraseroconvertedwhile76(63.3%)gavealowseroconversionrateof37.0%.ResultsshowedthatMVabsineitherseraorbreastmilkofmothersdidnotinterferwithMVvaccinationintheirchildren.Thelowseroconversionrateobtainedwasduetolowvaccinepotencywithtitersrangingbetween(log10-1.0–log10-2.5)TCID/perdose.Thiswasbesideothernon-specificantiviralsubstancesexhibitedvirusneutralizingactivity.

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