Does Lycopene Decrease the Inflammation in Airway Epithelial Cells?

Journal of Applied Biological Sciences

Ali Malekshahi MOGHADAM¹  Ahmad SAEDISOMEOLIA¹ 

关键词: Antioxidant;    Asthma;    Inflammation;    Lycopene;    Nuclear factor- kappa B;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Thesignificanceofairwayinflammationinasthmahasbeencompletelyunderstood.Oxidativestressalsoappearstoplayanimportantroleinthepathophysiologyofasthma.Lycopeneasapotentantioxidantandanti-inflammatoryagentisconsideredtoinhibitairwayinflammationintheasthmatics.Theaimofcurrentarticleistoreviewthelatestevidencesregardingtheimplicationoflycopeneinairwayinflammation.Forthispurpose,publishedPapersinU.S.NationalLibraryofMedicine–NationalInstitutesofHealth(Pubmed)werereviewed.Evidencesshowedthatlycopenecanprotectcellsfrominflammationviaitsredox-basedpropertyonsuppressionofnuclearfactor-kappaB(NF-κB),whichisakeynucleicfactorthatfacilitatestheproductionofinflammatorybiomarkers.Therefore,ithasbeensuggestedthatconsumingfreshvegetablesandfruits(especiallytomato)asthesourcesoflycopenecanhelpasthmaticstodecreaseairwayinflammation.

【 授权许可】

Unknown