Effects of neuromodulator RPCH on short-term dynamics of a key synapse in an oscillatory network of crab Cancer borealis

Journal of Applied Biological Sciences

Farzan NADIM¹  Seher ATAMTURKTUR¹ 

关键词: synaptic plasticity;    depression;    stomatogastric;    crustacea;    central pattern generator;    neuromodulator;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Centralpatterngenerators(CPGs)generatetherhythmicmovementsinvertebratesandinvertebrates.CPGsmustbeabletoproducestablepatternstoproducetherhythmicmovement,andbeflexibletoadapttothechangingenvironment.CPGsaresubjecttoactivity-dependentplasticityandtheiractivityismodifiedbyneuromodulatorysubstances.Neuromodulatorsaltertheintrinsicpropertiesandsynapticstrength.Thisalterationmaythenmodulatetheflexibilityofthemotorpatterns.Thepyloricnetworkofthecrustaceanstomatogastricnervoussystemisawell-studiedCPGthatissubjecttoextensiveneuromodulation.Effectsofneuromodulatorsonintrinsicpropertiesofneuronshavebeenstudiedingreatdetail,buttheeffectsofneuromodulatorsontheshort-termplasticityofthesynapsesareoverlooked.Therefore,themaingoalofthisstudywastoexaminetheroleofneuromodulatorRPCHontheshort-termdynamicsofpyloricLPtoPDsynapse,akeysynapse,byusingthecrabCancerborealisasamodelsystem.Ourresultsshowedthat,RPCHstrengthenedtheLPtoPDsynapseinadose-dependentmanner,depressedthesynapse,butdidnotaffectthepeakphase.Resultsofthisstudypromotetheunderstandingofhowmodulationofshort-termsynapticdynamicsofakeysynapseaffectsthegenerationandthecontrolofthepyloricrhythm.TheseresultswillhelptobetterunderstandthemechanismsunderlyingpatterngenerationbyCPGsingeneral.Moreover,suchanunderstandingofmodulationofacircuitryusedinrhythmicbehaviorsshouldleadtotreatmentsofcertainillnessesorinjuriessuchasspinalcordinjury

【 授权许可】

Unknown