Molecular and genetic basis of depression

Journal of genetics

Madhumita Roy1²  Biplob Koch²  Shobhna Joshi¹  Madhu G. Tapadia1² 

[1] Department of Psychology, Banaras Hindu University, Varanasi 221 005, India$$;Department of Zoology, Banaras Hindu University, Varanasi 221 005, India$$

关键词: depression;    brain-derived neurotropic factor;    5-HT;    5-HTTLPR;    neurogenesis;    synaptic plasticity;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Joyousness or sadness is normal reaction to state of life. If any of these lead to certain semi-permanent changes in daily life, then it is termed as mental disorder. Depression is one of the mental disorders with a state of low mood and aversion to activities that exerts a negative effect on a person’s thoughts and behaviour. Adolescent group is probably the world’s largest active group of people, who are getting prone to this state of mind leading to their diminished mental and physical abilities. Depression is closely linked to stress and thus a chronic stressful life can increase the risk of depression. Depression is a complex disease having both genetic and environmental components as contributing factors. In this study an attempt has been made to put forward the understanding of the known genes and their functional relationships with depression and stress with special reference to BDNF and 5-HTTLPR. Analysis of common genetic variants associated with depression, especially in the members of a family who had a previous history, might help in identifying the individuals at risk prior to the onset of depression.

【 授权许可】

Unknown