Effects of High dose Lead Toxication on Liver, Kidneys, Heart, Brain and Blood in Rabbits: An Experimental Study

Journal of Applied Biological Sciences

Ramazan Durgut¹  Ramazan Gonenci¹  M. Enes Altug¹  Murat Guzel¹  Ramazan Bal,Sefa Celik¹  Ahmet Koc¹  E. Ozlem Atesoglu¹ 

关键词: Lead toxication;    Haematology;    Biochemistry;    ECG;    Histopathology;    Ultrasonography;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Theaimofthestudywastoinvestigateeffectsofhighdoselead(Pb)exposureonheart,blood,kidney,liverandbraininrabbitsusingclinical,electrocardiographical(ECG),ultrasonographical,haematological,biochemicalandpathologicalmethods.Theexperimentswereperformedon15maleNewZealandrabbits,dividedintothreeequalgroupsandwereorallygiven80ppmor160ppmPbfor15daysandtheothergroupwasusedascontrol.Administrationof80or160ppmleadsignificantlyincreasedtheactivitiesofserumaspartateaminotransferase(AST),alaninaminotransferase(ALT),lactatedehydrogenase(LDH),creatinephosphokinase(CPK)andalkalinephosphatase(ALP).Hemoglobin(HB)andhematocrit(HCT)valuesweresignificantlylowerin80and160ppmPb-treatedanimalscomparedtothecontrolanimals(p<0.001).QRScomplexeswerewiderandamplitudesofTwavewerelargerintreatmentgroupscomparedtocontrogroup(p<0.05).Severehydropicandvacuolerdegenerationswereseeninhepatocytesandvacuolationanddegenerationofproximaltubularepithelialcellsincortexinthetreatmentgroupshistopathologically.Someneuronswereseverelydegenerated,andsevereneuronnecroseswereseenincornuammonisofbothofthetreatmentgroups.SeveremononuclearcellinfiltrationswereobservedinWirchow-Robinspaces.Inconclusion,deleteriouseffectsobservedinliver,kidneyandbloodinhighdosesofleadadministrationwithsomesimilaritiestochronicoraladministrationoflowdoses.

【 授权许可】

Unknown