Cyclic Voltammetry of Trazodone as [piperazin-1-yl] Antidepressant Drug and Bovine Serum Albumin Binding

Journal of Basic and Applied Sciences

Arooj Fatima¹  Iffat Azeem¹  Shaikh Mohiuddin¹ 

关键词: Piperazine -1-yl class;    drug-protein binding;    electrochemical method development;    voltammetric parameter optimization;    serotonin antagonist and reuptake inhibitor.;   

DOI  :  

学科分类：生物科学（综合）

来源: Lifescience Global

【 摘 要 】

Theelectrochemicalbehavioroftrazodone(TRZ),2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-onehasbeeninvestigatednbsp;bycyclicvoltammertymeasurementsatglassycarbonworkingelectrode.Thevoltammetricmethodincludesselectionofsupportingelectrolyte,pH,scanrateandtemperatureoptimization;andmeasurementsofsomeotherbasicvoltammetricparameters.TheTRZoxidationpeaksaredecreasedasaresultofTRZ-BSAbinding.TRZ-BSAbindingmechanismisalsoestablished.

【 授权许可】

Unknown