Evaluation of procalcitonin for diagnostics of septic complications in hematological patients and stem cell transplant recipients

Cellular Therapy and Transplantation

Boris V. Afanasyev¹  Vladimir N. Vavilov¹  Mayya A. Toropova¹ 

关键词: chemotherapy;    HSCT;    immunosuppressive therapy;    sepsis;    biomarker;    procalcitonin;   

DOI  :  10.3205/ctt-2010-No9-abstract69

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Background:Sepsisandsepticshockareamongthemostdangerouscomplicationsinpatientsreceivingconventionalchemotherapy,hematopoieticstemcelltransplantation(HSCT),andimmunosuppressivetreatmentofgraft-versus-hostdisease(GVHD).Thesediagnosesshouldusuallyhaveadditionalconfirmationwithspecificbiomarkers,suchasprocalcitonin(PCT).Aim:TodetectthesignificanceandefficacyofPCTinthediagnosisofsepsisamonghematologicalpatients.Patientsandmethods:Twenty-fivepatientsreceivingchemotherapy(n=13),HSCT(n=6),andGVHDtreatment(n=6)withdiagnosedsepsiswereenrolledintothestudy.Atthetimeoftheinfection68%ofthemhadneutropenia,and88%fever.Diagnosisofsepsiswasprovidedbymicrobiologicalassay,quantitativeC-reactiveprotein(100%positive),andadditionallyverifiedbyasemi-quantitativePCT-test(declaredpositiveatlevelsgreaterthan2.0ng/ml).Microbiologicaldetectionwasachievedin72%ofcases(n=18).Results:ThemedianofPCTwasgt;2.0ng/ml.PCTconcentrationsweregt;10.0ng/mlin52%,gt;2.0ng/mlin24%,gt;0.5ng/mlin8%,andlt;0.5ng/mlin16%ofcases.AmongthepatientswhoweresepsispositivePCTwasobservedin75%,withseveresepsisin72.7%,andwithsepticshockin80%ofcases.In28%ofpatientsPCTwasgt;2.0ng/mlwhilethemicrobiologywasnegative.ThreepatientswithoutfeverandpositivemicrobiologyhadaPCTconcentrationgt;2.0ng/ml.Conclusions:PCTisavaluablemarkerofsepsisandsepticshockinhematologicalpatientsandHSCTrecipientsevenwhenthebacteriologicaltestisnegativeandincaseswhenthepatientisafebrile.

【 授权许可】

Unknown