Journal of Oral Microbiology | |
Progress in oral personalized medicine: contribution of ‘omics’ | |
关键词: microbiota; precision medicine; ‘omics’; big data; biomarkers; | |
DOI : | |
来源: Co-Action Publishing | |
【 摘 要 】
Background:Precisionmedicine(PM),representingclinicallyapplicablepersonalizedmedicine,proactivelyintegratesandinterpretsmultidimensionalpersonalhealthdata,includingclinical,‘omics’,andenvironmentalprofiles,intoclinicalpractice.RealizationofPMremainsinprogress.Objective:Thefocusofthisreviewistoprovideadescriptivenarrativeoverviewof:1)thecurrentstatusoforalpersonalizedmedicine;and2)recentadvancesingenomicsandrelated‘omic’andemergingresearchdomainscontributingtoadvancingoral-systemicPM,withspecialemphasisoncurrentunderstandingoforalmicrobiomes.Design:Ascanofpeer-reviewedliteraturedescribingoralPMor‘omic’-basedresearchconductedonhumans/datapublishedinEnglishwithinthelast5yearsinjournalsindexedinthePubMeddatabasewasconductedusingmeshsearchterms.Anevidence-basedapproachwasusedtoreportonrecentadvanceswithpotentialtoadvancePMinthecontextofhistoricalcriticalandsystematicreviewstodelineatecurrentstate-of-the-arttechnologies.Specialfocuswasplacedonoralmicrobiomeresearchassociatedwithhealthanddiseasestates,emergingresearchdomains,andtechnologicaladvances,whicharepositioningrealizationofPM.Results:Thisreviewsummarizes:1)evolvingconceptualizationofpersonalizedmedicine;2)emerginginsightintorolesoforalinfectiousandinflammatoryprocessesascontributorstobothoralandsystemicdiseases;3)communityshiftsinmicrobiotathatmaycontributetodisease;4)evidencepointingtonewuncharacterizedpotentialoralpathogens;5)advancesintechnologicalapproachesto‘omics’researchthatwillacceleratePM;6)emergingresearchdomainsthatexpandinsightsintohost–microbeinteractionincludinginter-kingdomcommunication,systemsandnetworkanalysis,andsalivaomics;and7)advancesininformaticsandbigdataanalysiscapabilitiestofacilitateinterpretationofhostandmicrobiome-associateddatasets.Furthermore,progressinclinicallyapplicablescreeningassaysandbiomarkerdefinitiontoinformclinicalcarearebrieflyexplored.Conclusion:AdvancementoforalPMcurrentlyremainsinresearchanddiscoveryphases.Althoughsubstantiveprogresshasbeenmadeinadvancingtheunderstandingoftheroleofmicrobiomedynamicsinhealthanddiseaseandisbeingleveragedtoadvanceearlyeffortsatclinicaltranslation,furtherresearchisrequiredtodiscerninterpretableconstituencypatternsinthecomplexinteractionsofthesemicrobialcommunitiesinhealthanddisease.Advancesinbiotechnologyandbioinformaticsfacilitatingnovelapproachestorapidanalysisandinterpretationoflargedatasetsareprovidingnewinsightsintooralhealthanddisease,potentiatingclinicalapplicationandadvancingrealizationofPMwithinthenextdecade.Keywords:microbiota;precisionmedicine;‘omics’;bigdata;biomarkers(Published:4September2015)Citation:JournalofOralMicrobiology2015,7:28223-http://dx.doi.org/10.3402/jom.v7.28223
【 授权许可】
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