Bacterial profiles of saliva in relation to diet, lifestyle factors, and socioeconomic status

Journal of Oral Microbiology

Daniel Belstrøm⁸  Palle Holmstrup⁸  Berit L. Heitmann⁶  Vanja Klepac-Ceraj²  Claus H. Nielsen⁴  Bruce J. Paster¹  Nikolai Kirkby³  Nils-Erik Fiehn⁵  Svante Twetman⁷ 

[1] The Forsyth Institute, Department of Microbiology, Cambridge, MA, USADepartment of Oral Medicine, Infection & Immunity, Harvard School of Dental Medicine, Boston, MA, USA;Department of Biological Sciences, Wellesley College, Wellesley, MA, USA;Department of Medical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark;Department of International Health, Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark;Institute of Preventive Medicine, Bispebejerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, DenmarkThe Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, University of Sydney, AustraliaNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark;Section of Cariology, School of Dentistry, Faculty of Health Science, University of Copenhagen, Denmark;Section of Periodontology, School of Dentistry, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

关键词: Saliva;    HOMIM;    bacteria;    diet;    lifestyle;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Backgroundandobjective:Thebacterialprofileofsalivaiscomposedofbacteriafromdifferentoralsurfaces.Theobjectiveofthisstudywastodeterminewhetherdifferentdietintake,lifestyle,orsocioeconomicstatusisassociatedwithcharacteristicbacterialsalivaprofiles.Design:Stimulatedsalivasamplesfrom292participantswithlowlevelsofdentalcariesandperiodontitis,enrolledintheDanishHealthExaminationSurvey(DANHES),wereanalyzedforthepresenceofapproximately300bacterialspeciesbymeansoftheHumanOralMicrobeIdentificationMicroarray(HOMIM).Usingpresenceandlevels(meanHOMIM-value)ofbacterialprobesasendpoints,theinfluenceofdietintake,lifestyle,andsocioeconomicstatusonthebacterialsalivaprofilewasanalyzedbyMann–WhitneytestswithBenjamini–Hochberg’scorrectionformultiplecomparisonsandprincipalcomponentanalysis.Results:Targetsfor131differentprobeswereidentifiedin292samples,withStreptococcusandVeillonellabeingthemostpredominantgeneraidentified.Twobacterialtaxa(StreptococcussobrinusandEubacterium[11][G-3]brachy)weremoreassociatedwithsmokersthannon-smokers(adjustedp-valueamp;lt;0.01).Stratificationofthegroupbasedonextremeendsoftheparametersage,gender,alcoholconsumption,bodymassindex(BMI),anddietintakehadnostatisticalinfluenceonthecompositionofthebacterialprofileofsaliva.Conversely,differencesinsocioeconomicstatuswerereflectedbythebacterialprofilesofsaliva.Conclusions:Thebacterialprofileofsalivaseemsindependentofdietintake,butinfluencedbysmokingandmaybesocioeconomicstatus.Keywords:saliva;HOMIM;bacteria;dietlifestyle(Published:1April2014)Citation:JournalofOralMicrobiology2014,6:23609-http://dx.doi.org/10.3402/jom.v6.23609

【 授权许可】

Unknown