Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus

International Journal of Physiology, Pathophysiology and Pharmacology

Alonso Martinez-Canabal¹  James J. Bae¹  Paul W. Frankland¹  Yun-Yan Xiang¹  Wei-Yang Lu¹  Burton B. Yang¹ 

[1] Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Anesthesia, Department of Physiology, Institute of Medical Science, University of Toronto; Program in Neurosciences and Mental Health, Hospital for Sick Children; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

关键词: Cytokine;    astrocytes;    microglia;    glutamate receptor;    neurodegeneration;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Transforminggrowthfactor-beta1(TGF-#946;1)isaninflammation-relatedcytokine.Itsexpressioninthebrainincreasesunderconditionsofneurodegenerativediseasesandinjury.PreviousstudieshaveshownthatgenomicalterationsofTGF-#946;1expressioninthebraincauseneurodegenerativechangesinagedmice.ThepresentstudyrevealedthatincreasedproductionofTGF-#946;1intransgenicmiceresultedingliosisatyoungages.Inaddition,theincreasedTGF-#946;1augmentedtheexpressionofsomekeysubunitsof#945;-amino-3-hydroxy-5-methyl-4-isoxazoleproprionicacid(AMPA)andN-methyl-D-aspartate(NMDA)receptorsinthehippocampus.TreatmentofculturedhippocampalneuronswithTGF-#946;1facilitatedneuriteoutgrowthandenhancedglutamate-evokedcurrents.Together,thesedatasuggestthatincreasedTGF-#946;1altersionotropicglutamatereceptorexpressionandfunctioninthehippocampus.(IJPPP1008005).

【 授权许可】

Unknown