Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction☆

Developmental Biology

Keith A Wharton Jr.¹ 

[1] Departments of Pathology, Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390-9072

关键词: Wnt;    Wingless;    Wg;    Dishevelled;    Dsh;    Dvl;    Frizzled;    Fz;    Armadillo;    Arm;    β-catenin;    planar cell polarity;    tissue polarity;    convergent extension;   

DOI  :  10.1006/dbio.2002.0869

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

WntproteinstransmitmyriadintercellularsignalscrucialforthedevelopmentandhomeostasisofmetazoananimalsfromHydratohuman.AbnormalWntsignalingcausesagrowingnumberofdiseases,includingcancerandosteoporosis.Dependingonthecontext,agivenWntsignalmaydenote:cellproliferationorapoptosis;cellfatedetermination,differentiation,orstemcellmaintenance;avarietyofchangesincellbehavior;and/orcoordinatedinteractionswithitsneighbors.Whichevent(s)occurinWnt-responsivecellsdependscriticallyontheabilityofDishevelled(Dsh)/Dvlproteinstointerpretdistincttypesofintracellular,receptor-generatedstimuliandtransmitthemtoatleasttwodistinctsetsofeffectormolecules,allwhileapparentlyignoringathirdtypeofWnt-generatedCa2+signal.ThethreeconserveddomainspresentinDsh/DvlproteinsuniquelyfunctionineachWntpathway,inpartbyassociationwith18(andcounting)Dsh/Dvl-associatedproteins.ThelatestdatasuggestthatDsh/Dvlproteinsorganizedynamic,pathway-specificsubcellularsignalingcomplexesthatensurecorrectinformationrouting,signalamplification,anddynamiccontrolthroughfeedbackregulation.ThebiochemicalandcellbiologicalmechanismsbywhichDsh/Dvlproteinsaccomplishtheseremarkabletasksremainobscure.

【 授权许可】

Unknown