Stripe Provides Cues Synergizing with Branchless to Direct Tracheal Cell Migration

Developmental Biology

Talila Volk¹  Ruslan Dorfman¹  Ben-Zion Shilo¹ 

[1] Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel

关键词: Drosophila;    trachea;    FGF;    Branchless;    Stripe;    EGR;    cell migration;   

DOI  :  10.1006/dbio.2002.0836

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

TheDrosophilatrachealsystemisaninterconnectedtubularrespiratorynetwork,whichisformedbydirectedstereotypicmigrationandfusionofbranches.Cellmigrationandspecificationaredeterminedbycombinatorialsignalingofseveralmorphogenssecretedfromtheectoderm.Wereportthediscoveryofagroupofectodermalcells,markedbyStripe(Sr)expression,thatcoordinatestrachealcellmigrationinthedorsoventralaxis.Sr,anEGRfamilytranscriptionfactor,isknowntoregulatemusclemigration.Inthisstudy,weshowthatSrectodermalcellsalsoprovidesignalsthatareutilizedfortrachealmigration.Thesecuesareseparatedinthetimecourseofembryonicdevelopment.Initially,tendon-precursorcellsareincloseproximitytothetrachealcells,andlater,whentrachealmigrationiscomplete,themusclesdisplacethetracheaandattachtothetendoncells.sr-mutantembryosexhibitdefectsinmigrationofalltrachealbranches.AlthoughtheFGFligandBranchless(Bnl)isexpressedinasubsetoftendon-precursorcellsindependentlyofSr,BnlfunctionscooperativelywithproteinsinducedbySrinattractionoftrachealbranches.

【 授权许可】

Unknown