Developmental Biology | |
Stripe Provides Cues Synergizing with Branchless to Direct Tracheal Cell Migration | |
Talila Volk1  Ruslan Dorfman1  Ben-Zion Shilo1  | |
[1] Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel | |
关键词: Drosophila; trachea; FGF; Branchless; Stripe; EGR; cell migration; | |
DOI : 10.1006/dbio.2002.0836 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
TheDrosophilatrachealsystemisaninterconnectedtubularrespiratorynetwork,whichisformedbydirectedstereotypicmigrationandfusionofbranches.Cellmigrationandspecificationaredeterminedbycombinatorialsignalingofseveralmorphogenssecretedfromtheectoderm.Wereportthediscoveryofagroupofectodermalcells,markedbyStripe(Sr)expression,thatcoordinatestrachealcellmigrationinthedorsoventralaxis.Sr,anEGRfamilytranscriptionfactor,isknowntoregulatemusclemigration.Inthisstudy,weshowthatSrectodermalcellsalsoprovidesignalsthatareutilizedfortrachealmigration.Thesecuesareseparatedinthetimecourseofembryonicdevelopment.Initially,tendon-precursorcellsareincloseproximitytothetrachealcells,andlater,whentrachealmigrationiscomplete,themusclesdisplacethetracheaandattachtothetendoncells.sr-mutantembryosexhibitdefectsinmigrationofalltrachealbranches.AlthoughtheFGFligandBranchless(Bnl)isexpressedinasubsetoftendon-precursorcellsindependentlyofSr,BnlfunctionscooperativelywithproteinsinducedbySrinattractionoftrachealbranches.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912090729335ZK.pdf | 75KB | download |