Crossing the Ventral Midline Causes Neurons to Change Their Response to Floor Plate and Alar Plate Attractive Cues during Transmedian Migration

Developmental Biology

Fujio Murakami¹  Hiroki Taniguchi¹  Timothy E Kennedy¹  Atsushi Tamada¹ 

[1] Division of Behavior and Neurobiology, National Institute for Basic Biology, Myodaiji-cho, Okazaki, 444-8585, Japan

关键词: tangential migration;    transmedian migration;    precerebellar neurons;    floor plate;    alar plate;    netrin-1;    attraction;   

DOI  :  10.1006/dbio.2002.0763

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Neuronalmigrationisrequiredfortheestablishmentofspecificneuralstructures,suchaslayersandnuclei.Neuronsmigratealongspecificmigratoryroutestowardtheirfinaldestinations,sometimesacrosslongdistances.However,thecellularandmolecularinteractionsthatcontrolneuronalmigrationarelargelyunknown.Here,weexaminedthemechanismunderlyingthetransmedianmigrationofprecerebellarneuronsusingaflatwhole-mountpreparationoftheratembryo.Theseneuronswereinitiallyattractedbythefloorplate(FP)attheventralmidline.However,aftercrossingthemidline,theylosttheirresponsivenesstotheFPandbecameattractedbythealarplate(AP).AlthoughthelossofresponsivenesstoFPcueswascausedbyanencounterofmigratingcellswiththeFP,thegainofresponsivenesstoAPcuesoccurredirrespectiveoftheirencounterwiththeFP.Theseresultsidentifyacrucialchangeintheresponseofmigratingcellstoattractiveguidancecuesduringthetransmedianmigrationofprecerebellarneurons.

【 授权许可】

Unknown