The Avian Telencephalic Subpallium Originates Inhibitory Neurons That Invade Tangentially the Pallium (Dorsal Ventricular Ridge and Cortical Areas)

Developmental Biology

Inmaculada Cobos¹  Luis Puelles¹  Salvador Martínez¹ 

[1] Department of Morphological Sciences, School of Medicine, University of Murcia, Murcia, 30100, Spain

关键词: Interneuron;    GABA;    subpallium;    cortex;    DVR;    telencephalon;    tangential migration;    neuronal specification;   

DOI  :  10.1006/dbio.2001.0422

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

RecentdataonthedevelopmentofthemammalianneocortexsupportthatthemajorityofitsinhibitoryGABAergicinterneuronsoriginatewithinthesubpallium(ganglioniceminences).Supportforsuchtangentialmigrationintothepalliumhascomefromexperimentsusingfluorescenttracersorlineageanalysiswithretrovirus,andthephenotypesofmutantmicewithdifferentabnormalitiesinthedevelopingsubpallium.Inthepresentstudy,wedescribetangentialmigrationofsubpallial-derivedneuronsinthedevelopingchicktelencephalon.Usingquail–chickgrafts,wepreciselyidentifiedtheneuroepithelialorigin,time-course,andpathwaysofmigration,aswellastheidentityandrelativedistributionofthediversetangentiallymigratedneurons.Theanalysisofselectivegraftsofthepallidalandstriatalprimordiaallowedustodeterminetherelativecontributionofeachprimordiumtothepopulationofmigratingneurons.Moreover,wefoundthat,likeinmammals,thevastmajorityoftheGABAergicandcalbindin-immunoreactiveneuronswithinthepallium(dorsalventricularridgeandcorticalareas)haveanextracortical,subpallialorigin.Ourresultssuggestthatthetelencephalonofbirdsandmammalssharedevelopmentalmechanismsfortheoriginandmigrationoftheircorticalinterneurons,whichprobablyfirstevolvedatanearlierstageintheradiationofvertebratesthanwasthoughtbefore.

【 授权许可】

Unknown