Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol

Journal of Neurodevelopmental Disorders

Alberto Granato¹  Francesca Sangiuliano Intra¹  Sara E Comparini¹  Andrea De Giorgio¹ 

[1] Department of Psychology, Catholic University, L.go A. Gemelli 1, Milan 20123, Italy

关键词: Voronoi tessellation;    Striatum;    Parvalbumin;    Interneuron;    GABA;    Fetal alcohol;   

Others  :  811798
DOI  :  10.1186/1866-1955-4-18

 received in 2012-03-29, accepted in 2012-06-18,  发布年份 2012

【 摘 要 】

Background

Exposure to alcohol in utero is a known cause of mental retardation. Although a certain degree of motor impairment is always associated with fetal alcohol spectrum disorder, little is known about the neurobiological basis of the defective motor control. We have studied the striatal interneurons containing parvalbumin in a rat model of fetal alcohol spectrum disorder.

Methods

Newborn rats received ethanol by inhalation from postnatal day two through six and parvalbumin striatal neurons were labeled by immunohistochemistry on postnatal day 60. The spatial distribution of parvalbumin interneurons was studied using Voronoi spatial tessellation and their dendritic trees were completely reconstructed.

Results

Parvalbumin interneurons of ethanol-treated animals showed a clustered spatial distribution similar to that observed in control animals. The dendritic tree of parvalbumin interneurons was significantly reduced in ethanol-treated animals, as compared with controls.

Conclusions

Striatal parvalbumin interneurons are crucial components of the brain network serving motor control. Therefore, the shrinkage of their dendrites could contribute to the motor and cognitive symptoms observed in fetal alcohol spectrum disorder.

【 授权许可】

   
2012 De Giorgio et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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