Conservation of Brachyury, Mef2, and Snail in the Myogenic Lineage of Jellyfish: A Connection to the Mesoderm of Bilateria

Developmental Biology

Christoph Jösch¹  Brigitte Winninger¹  Jürg Spring¹  Volker Schmid¹  Nathalie Yanze¹  Arnoud M. Middel¹ 

[1] Institute of Zoology, University of Basel, Biocenter/Pharmacenter, Klingelbergstrasse 50, CH-4056, Basel, Switzerland

关键词: cnidaria;    mesoderm;    evolution;    myogenesis;    regulatory genes;   

DOI  :  10.1006/dbio.2002.0616

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Onemajordifferencebetweensimplemetazoanssuchascnidariansandallthebilateriananimalsisthoughttoinvolvetheinventionofmesoderm.Thetermsdiploblastsandtriploblastsaretherefore,oftenusedtogroupprebilaterianandbilateriananimals,respectively.However,jellyfishcontainwelldevelopedstriatedandsmoothmuscletissuesthatderivefromtheentocodon,amesoderm-liketissueformedduringmedusadevelopment.Weinvestigatedthehypothesis,thattheentocodoncouldbehomologoustothethirdgermlayerofbilateriansbyanalyzingthestructuresandexpressionpatternsofthehomologuesofBrachyury,Mef2,andSnailinthejellyfishPodocorynecarnea.TheseareregulatorygenesfromtheT-box,MADS-boxandzincfingerfamiliesknowntoplayimportantrolesinbilaterianmesodermpatterningandmuscledifferentiation.ThesequenceandexpressiondatademonstratethatthegenesarestructurallyandfunctionallyconservedandevenmoresimilartohumansorotherdeuterostomesthantoprotostomemodelorganismssuchasDrosophilaorCaenorhabditiselegans.Basedonthesedataweconcludethatthecommonancestorofthecnidariansandbilateriansnotonlysharedgenesthatplayaroleinregulatingmyogenesisbutalreadyusedthemtodevelopanddifferentiatemusclesystemssimilartothoseoftriploblasts.

【 授权许可】

Unknown