Developmental Biology | |
Identification and Characterization of a Calcium Channel γ Subunit Expressed in Differentiating Neurons and Myoblasts | |
Anne K. Knecht1  Brent M. Kious1  Marianne Bronner-Fraser1  Clare V.H. Baker1  | |
[1] Division of Biology, 139-74, California Institute of Technology, Pasadena, California, 91125 | |
关键词: CACNG4 (γ4); calcium channel; neuronal differentiation; myoblasts; cranial ganglia; placodes; | |
DOI : 10.1006/dbio.2001.0570 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
Transientelevationsofintracellularcalcium(calciumtransients)playcriticalrolesinmanydevelopmentalprocesses,includingdifferentiation.Althoughthefactorsthatregulatecalciumtransientsarenotclearlydefined,calciuminfluxmaybecontrolledbymoleculesinteractingwithcalciumchannels,includingchannelregulatorysubunits.Here,wedescribethechickγ4regulatorysubunit(CACNG4),thefirstsuchsubunittobecharacterizedinearlydevelopment.CACNG4isexpressedearlyinthecranialneuralplate,andlaterinthecranialanddorsalrootganglia;importantly,thetimingofthislaterexpressioncorrelatespreciselywiththeonsetofneuronaldifferentiation.CACNG4expressionisalsoobservedinnonneuronaltissuesundergoingdifferentiation,specificallythemyotomeandasubpopulationofdifferentiatingmyoblastsinthelimbbud.Finally,withinthedistalcranialganglia,weshowthatCACNG4isexpressedinplacode-derivedcells(prospectiveneurons),butalso,surprisingly,inneuralcrest-derivedcells,previouslyshowntoformonlygliainthislocation;contrarytothesepreviousresults,wefindthatneuralcrestcellscanformneuronsinthedistalganglia.GiventheproposedroleofCACNG4inmodulatingcalciumchannelsanditsexpressionindifferentiatingcells,wesuggestthatCACNG4maypromotedifferentiationviaregulationofintracellularcalciumlevels.
【 授权许可】
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