Cellular Dispersion Patterns and Phenotypes in the Developing Mouse Superior Colliculus

Developmental Biology

Seong-Seng Tan¹  Alan Harvey¹  Helen Valcanis¹  Michael Kalloniatis¹ 

[1] Brain Development Group, Howard Florey Institute, The University of Melbourne, Parkville, Victoria, Australia

关键词: superior colliculus;    chimeras;    radial migration;    tangential dispersion;    glutamate;    GABA;   

DOI  :  10.1006/dbio.2001.0505

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Themammaliansuperiorcolliculusisstructurallyandfunctionallydividedintotwoentities:superficialvisualanddeepmultimodalmotor.Todiscovertherole,ifany,ofdevelopmentalprocessesinestablishingseparatetectalcompartments,wehaveusedhighlyunbalancedmousechimaerastomarkcelldispersionpathwaysandtracecelllineages.Twoformsofcelldispersionweredetected:radialandtangential.Neitherradialnortangentialformsofcelldispersionwerefoundtoexistontheirowninanygroupoflabeledcells.Radialcelldispersionwasthepredominantformofcellmovementfromthegerminalzonesandprimarilyassociatedwiththedifferentiationofglutamatergicneurons.Incontrast,tangentialcelldispersioninvolvedaminorityoftectalcells,concentratedchieflyinthesuperficiallayersandoftenassociatedwiththeupperaspectsofradialcolumns.Morescatteredcellsexpressedγ-aminobutyricacid(GABA)comparedtocolumnarcells.Takentogether,theseresultsindicateseparatedevelopmentalconstraintsforthedevelopmentofglutamatergicandGABAergicneuronsinthesuperiorcolliculus.

【 授权许可】

Unknown