Ion Transport in Sperm Signaling

Developmental Biology

Takuya Nishigaki¹  Ricardo Felix¹  Carmen Beltrán¹  Alberto Darszon¹  Claudia L. Treviño¹ 

[1] Departamento de Genética y Fisiologı́a Molecular, Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, 62250, México

关键词: acrosome reaction;    capacitation;    fertilization;    ion channels;    ion transport;    sperm;    spermatogenic cells;   

DOI  :  10.1006/dbio.2001.0387

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Ionchannelsandtransporters,keyelementsinsperm–eggsignalingandenvironmentalsensing,areessentialforfertilization.Externalcuesandcomponentsfromtheouterenvelopesoftheegginfluencespermionpermeabilityandbehavior.Combininginvivomeasurementsofmembranepotential,intracellularions,andsecondmessengerswithnewmolecularapproachesandreconstitutionstrategiesarerevealinghowspermionchannelsparticipateinmotility,spermmaturation,andtheacrosomereaction.Spermaretinydifferentiatedterminalcellsunabletosynthesizeproteinsanddifficulttocharacterizeelectrophysiologically.Spermatogeniccells,theprogenitorsofsperm,havebecomeusefultoolsforprobingspermionchannelssincetheyarelargerandmolecularbiologytechniquescanbeapplied.Thesecomplementarystrategiesareopeningnewavenuestodeterminehowspermionchannelsfunctioningametesignaling.

【 授权许可】

Unknown