The BTB/POZ Domain of the Regulatory Proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) Interacts with the Novel Drosophila TAFII Factor BIP2/dTAFII155

Developmental Biology

Jean-Christophe Pointud¹  Bernard Dastugue¹  Jan Larsson¹  Jean-Louis Couderc¹ 

[1] Institut National de la Santé et de la Recherche Médicale U384, Laboratoire de Biochimie, UFR Médecine, 28, place Henri Dunant, 63001, Clermont-Ferrand, France

关键词: BTB/POZ domain;    TAFII;    Drosophila;    transcriptional regulation;   

DOI  :  10.1006/dbio.2001.0358

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

TheBTB/POZdomainisanevolutionarilyconservedprotein–proteininteractiondomainpresentintheN-terminalregionofnumeroustranscriptionfactorsinvolvedindevelopment,chromatinremodeling,andhumancancers.ThisdomainisinvolvedinhomomericandheteromericassociationswithotherBTB/POZdomains.TheDrosophilaBTB/POZproteinsBricàbrac1(BAB1)andBricàbrac2(BAB2)aredevelopmentallyregulatedtranscriptionfactorswhichareinvolvedinpatternformationalongtheproximo-distalaxisofthelegandantenna,inthemorphogenesisoftheadultovaries,andinthecontrolofsexuallydimorphiccharacters.WehaveidentifiedpartnersoftheBAB1proteinbyusingthetwo-hybridsystem.Thecharacterizationofoneoftheseproteins,calledBIP2forBABInteractingProtein2,ispresented.BIP2isanovelDrosophilaTATA-boxProteinAssociatedFactor(TAFII),alsonameddTAFII155.WeshowthattheBTB/POZdomainsofBAB1andBAB2aresufficienttomediateadirectinteractionwithBIP2/dTAFII155.ThisprovidesadirectlinkbetweentheseBTB/POZtranscriptionfactorsandthebasaltranscriptionalmachinery.WediscusstheimplicationsoftheinteractionbetweenaBTB/POZdomainandaTAFIIforthemolecularmechanismsoftranscriptionalcontrolmediatedbyBTB/POZtranscriptionfactors.

【 授权许可】

Unknown