Developmental Biology | |
The BTB/POZ Domain of the Regulatory Proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) Interacts with the Novel Drosophila TAFII Factor BIP2/dTAFII155 | |
Jean-Christophe Pointud1  Bernard Dastugue1  Jan Larsson1  Jean-Louis Couderc1  | |
[1] Institut National de la Santé et de la Recherche Médicale U384, Laboratoire de Biochimie, UFR Médecine, 28, place Henri Dunant, 63001, Clermont-Ferrand, France | |
关键词: BTB/POZ domain; TAFII; Drosophila; transcriptional regulation; | |
DOI : 10.1006/dbio.2001.0358 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
TheBTB/POZdomainisanevolutionarilyconservedprotein–proteininteractiondomainpresentintheN-terminalregionofnumeroustranscriptionfactorsinvolvedindevelopment,chromatinremodeling,andhumancancers.ThisdomainisinvolvedinhomomericandheteromericassociationswithotherBTB/POZdomains.TheDrosophilaBTB/POZproteinsBricà brac1(BAB1)andBricà brac2(BAB2)aredevelopmentallyregulatedtranscriptionfactorswhichareinvolvedinpatternformationalongtheproximo-distalaxisofthelegandantenna,inthemorphogenesisoftheadultovaries,andinthecontrolofsexuallydimorphiccharacters.WehaveidentifiedpartnersoftheBAB1proteinbyusingthetwo-hybridsystem.Thecharacterizationofoneoftheseproteins,calledBIP2forBABInteractingProtein2,ispresented.BIP2isanovelDrosophilaTATA-boxProteinAssociatedFactor(TAFII),alsonameddTAFII155.WeshowthattheBTB/POZdomainsofBAB1andBAB2aresufficienttomediateadirectinteractionwithBIP2/dTAFII155.ThisprovidesadirectlinkbetweentheseBTB/POZtranscriptionfactorsandthebasaltranscriptionalmachinery.WediscusstheimplicationsoftheinteractionbetweenaBTB/POZdomainandaTAFIIforthemolecularmechanismsoftranscriptionalcontrolmediatedbyBTB/POZtranscriptionfactors.
【 授权许可】
Unknown
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