“Challenge to Conquer Cancer—New Trends in Mutation Research” JEMS Open Symposium 2011

Genes and Environment

Tatsuo Nunoshiba²  Yuko Ibuki³  Isao Kuraoka¹  Issay Narumi⁴ 

[1] Graduate School of Engineering Science, Osaka University;International Christian University;Graduate School of Nutrition and Environmental Science, University of Shizuoka;Quantum Beam Science Directorate, Japan Atomic Energy Agency

关键词: translesion DNA polymerase;    post-replication repair;    lesion bypass;    Hsp90;    genome-wide association study (GWAS);   

DOI  :  10.3123/jemsge.34.55

学科分类：分子生物学，细胞生物学和基因

来源: Japanese Environmental Mutagen Society / Nihon Kankyo Hen igen Gakkai

【 摘 要 】

References(8)Conquering cancer is one of the most crucial missions for researchers of environmental mutagenesis and carcinogenesis. One effective approach to understanding carcinogenesis involves elucidating how mutations are fixed from DNA lesions induced by environmental mutagens and carcinogens and how DNA polymerases and intracellular functions related to these polymerases are involved in the mutation fixation. These are rather old-fashioned but still critical questions that should be clarified. Recent analyses using novel molecular biology and genome epidemiology techniques could be powerful weapons to make open this “black box.” Seven scientists who were working to elucidate the molecular mechanisms for environmental mutagenesis and carcinogenesis were invited to the Public Symposium of the Japanese Environmental Mutagen Society (JEMS) held on May 28, 2011; they discussed the aims of mutation research in the next generation to conquer cancer.

【 授权许可】

Unknown