Induction of Apoptosis in a Human Breast Cancer Cell Overexpressing ErbB-2 Receptor by α-Tocopheryloxybutyric Acid

The Japanese Journal of Pharmacology

Akihiko Akazawa³  Ryuji Asano³  Sung Jae Shin²  Kazuyuki Suzuki³  Kiyokazu Hagiwara²  Itsumaru Kumadaki¹  Kazuhiro Nishikawa³  Tomohiro Yano²  Haruna Satoh² 

[1] Faculty of Pharmaceutical Sciences, Setsunan University;Department of Food Science Research for Health, National Institute of Health and Nutrition;Department of Veterinary Pharmacology, College of Bioresource Sciences, Nihon University

关键词: α-Tocopheryloxybutyric acid;    Apoptosis;    Breast cancer cell;   

DOI  :  10.1254/jjp.89.417

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(13)The overexpression of ErbB-2 receptor relates to malignant transformation of breast cancer. The present study was carried out to establish the usefulness of α-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. TE caused induction of apoptosis in MDA-MB-453 cells overexpressing the ErbB-2 receptor. TE reduced levels of activated ErbB-2 receptor and Akt. In contrast, TE induced the activation of p38, and SB203580, a specific inhibitor for p38, attenuated the TE-induced apoptosis. These data indicate that simultaneous occurrences of Akt inhibition and p38 activation by TE result in the cell death.

【 授权许可】

Unknown