Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Neurons: Regional Difference in Serotonergic Modulation

The Japanese Journal of Pharmacology

Yuji Ikegaya¹  Yuki Iwahori¹  Norio Matsuki¹ 

[1] Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo

关键词: Nucleus of solitary tract;    Hyperpolarization-activated current;    Serotonin;   

DOI  :  10.1254/jjp.88.459

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (Ih) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of Ih compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated Ih amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate Ih channel activity in caudal and medial NTS neurons.

【 授权许可】

Unknown