Effects of a κ-Receptor Agonist U-50488 on Bulbar Respiratory Neurons and Its Antagonistic Action Against the μ Receptor-Induced Respiratory Depression in Decerebrate Cats

The Japanese Journal of Pharmacology

Akira Haji¹  Ryuji Takeda¹ 

[1] Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University

关键词: Respiratory neuron;    Phrenic nerve discharge;    κ Receptor-mechanism;   

DOI  :  10.1254/jjp.87.333

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)Cited-By(8)The function of κ receptor-mechanisms in bulbar respiratory network was investigated in decerebrate cats. Intravenous injection of U-50488 (0.3 – 3.0 mg/kg) dose-dependently decreased the phrenic nerve discharge and shortened inspiration and expiration. U-50488 caused hyperpolarization, and decreased input resistance and the action potential discharge in respiratory neurons. The effects of U-50488 were antagonized by nor-binaltorphimine. DAMGO (0.3 mg/kg, i.v.) decreased the phrenic discharge and prolonged inspiration and expiration. U-50488 partially reversed the respiratory depression induced by DAMGO. These results suggest that the activation of κ receptors by itself depresses the central respiratory activity, while it opposes the μ receptor-mediated respiratory depression.

【 授权许可】

Unknown