Contribution of NMDA Receptors to Activity of Augmenting Expiratory Neurons in Vagotomized Cats

The Japanese Journal of Pharmacology

Mari Okazaki¹  Akira Haji¹  Ryuji Takeda¹ 

[1] Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan

关键词: Respiratory neuron;    Intracellular recording;    NMDA receptor;   

DOI  :  10.1254/jjp.82.353

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)To identify the NMDA receptor-mediated mechanism in augmenting expiratory(E2)neurons, the effects of systemic and local application of dizocilpine on spontaneous and evoked postsynaptic potentials(PSPs)were investigated in decerebrate and vagotomized cats.Intravenously applied dizocilpine reduced the inhibitory PSPs during inspiration and stage 1 expiration, but had little effect on the excitatory PSPs during stage 2 expiration.Iontophoresed dizocilpine caused a continuous hyperpolarization throughout the respiratory cycle.Dizocilpine had no effect on vagally evoked PSPs.These results suggest that the NMDA mechanisms are involved presynaptically in periodic postsynaptic inhibitions and postsynaptically in tonic excitation in E2 neurons.

【 授权许可】

Unknown