Involvement of β2-Adrenergic and μ-Opioid Receptors in Antinociception Produced by Intracerebroventricular Administration of α,β-Methylene-ATP

The Japanese Journal of Pharmacology

Masato Fukui¹  Masamichi Satoh¹  Takayuki Nakagawa¹  Masabumi Minami¹ 

[1] Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University

关键词: α;    β-Methylene-ATP;    Antinociception;    β2-Adrenoceptor;    μ-Opioid receptor;    Intracerebroventricular;   

DOI  :  10.1254/jjp.86.423

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(36)Cited-By(5)The present study examined what kind of receptors are involved in the antinociception produced by intracerebroventricular (i.c.v.) administration of α,β-methylene-ATP using antagonists at adrenergic, serotonin or opioid receptors. Antinociceptive effect of α,β-methylene-ATP (10 nmol/rat) was significantly attenuated by subcutaneous pretreatment with propranolol and naloxone, but not phentolamine or methysergide, at a dose of 10 mg/kg. I.c.v. pretreatment with propranolol (100 nmol/rat), butoxamine (100 nmol/rat), ICI-118,551 (100 nmol/rat) and naloxone (30 nmol/rat) significantly attenuated the antinociceptive effect of α,β-methylene-ATP. However, i.c.v. pretreatment with atenolol (100 nmol/rat), naltrindole (30 nmol/rat) or nor-binaltorphimine (30 nmol/rat) did not show any significant effects. These results suggest that supraspinal β2-adrenergic and μ-opioid receptors are involved in the antinociceptive effect of i.c.v. administered α,β-methylene-ATP.

【 授权许可】

Unknown