The Japanese Journal of Pharmacology | |
Effects of β-Casomorphins on Neuronal Survival in Culture of Embryonic Chick Dorsal Root Ganglion Neurons | |
Tomoko Satoh1  Takeshi Fujimori1  Eiko Matsumura1  Minoru Sakaguchi1  | |
[1] Laboratory of Cell Biology, Osaka University of Pharmaceutical Sciences | |
关键词: β-Casomorphin; Neuronal survival; Chick dorsal root ganglion neuron; | |
DOI : 10.1254/jjp.86.363 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(13)Cited-By(3)We studied the effects of β-casomorphins (β-CMs, μ-acting opioid peptides from milk protein β-casein) on survival of primary-cultured chick dorsal root ganglion neurons in the presence of nerve growth factor. β-CM-5 and β-CM-7 had potent neuronal survival-promoting activities. β-CM-4 amide (morphiceptin) and des-Tyr1-β-CM-7 also exhibited the similar promoting effects, although their effects were very weak. The promoting effect of β-CM-5 was prevented by co-administration of naloxone, or pretreatment with pertussis toxin. These results suggest that the neuronal survival-promoting effects of β-CMs might be mediated through opioid receptors coupled to G proteins.
【 授权许可】
Unknown
【 预 览 】
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