Hormonal Effects of Z-350, Possessing Steroid 5α-Reductase Inhibitory and α1-Adrenoceptor Antagonistic Actions, in the Rat

The Japanese Journal of Pharmacology

Masayuki Ogishima¹  Tadashi Kurimoto¹  Kenji Yoshida¹  Youichi Fukuda¹  Raita Higashino¹  Mineo Takei¹  Yoshihisa Fukuta¹ 

[1] Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

关键词: Z-350;    Steroid 5α-reductase;    Benign prostatic hyperplasia;    Testosterone;    Dihydrotestosterone;   

DOI  :  10.1254/jjp.86.323

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(33)Cited-By(2)We examined the hormonal effects of Z-350, (S)-4-[3-(4-{1-(4-methylphenyl)-3-[4-(2-methoxyphenyl)piperazine-1-yl]propoxy}benzoyl)indole-1-yl]butyric acid hydrochloride, which has both α1-adrenoceptor blocking activity and steroid 5α-reductase inhibitory activity, in male and female rats. Z-350 administered orally for 14 days at a dose of 30 mg/kg to normal male rats significantly reduced the weight of the prostate and seminal vesicles without affecting the weight of the testis, epididymis, adrenals, kidney or liver. Prostatic levels of dihydrotestosterone decreased dose-dependently, with a slight increase in the level of testosterone at a Z-350 dose of 100 mg/kg. We observed no effects on the weight of the prostate in castrated rats or on the weight of the uterus in normal or 17β-estradiol-treated female rats. These results suggest that Z-350 inhibits prostatic growth via inhibition of steroid 5-reductase without other hormonal effects.

【 授权许可】

Unknown