Effects of Adenosine A1- and A2A-Receptor Agonists on Enhancement of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats

The Japanese Journal of Pharmacology

Shigenori Watanabe¹  Takako Fukumoto¹  Takao Shimazoe¹  Yukiko Doi¹  Takahide Shuto¹  Akiko Yoshimatsu¹  Atsuko Kawashimo¹ 

[1] Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University 62

关键词: Sensitization;    Dopamine;    Adenosine;   

DOI  :  10.1254/jjp.86.254

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(6)We report here both adenosine A1- and A2A-receptor agonists inhibit the expression of methamphetamine (MAP)-induced behavioral sensitization in rats. Animals were treated with MAP (1.0 mg /kg, i.p.) every 3 days with a total of 5 administrations. The augmentation of dopamine release from the striatum was demonstrated by MAP re-administration (0.5 mg/kg, i.p.) after 7-day withdrawal by microdialysis. The augmentation of dopamine release was inhibited by pre-treatment not with N6-cyclohexyladenosine (0.01 mg/kg, i.p.) but by with 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxy-amide adenosine (0.1 mg/kg, i.p.). These results suggested that adenosine A1 and A2A receptors play an inhibitory role in sensitization via different mechanisms.

【 授权许可】

Unknown