Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature

The Japanese Journal of Pharmacology

Koji Yajin³  Masaya Takumida³  Masashi Sasa¹  Tomohisa Hirai³  Noriaki Tanimitsu³  Hiroshi Watanabe³  Hiromichi Tsuru² 

[1] Department of Pharmacology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan;Department of Pharmacology, Toho University School of Medicine, 5-21-16 Ohmori-nishi, Ohta-ku, Tokyo 143-8540, Japan;Department of Otorhinolaryngology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan

关键词: Nasal mucosa vasculature;    Hydrogen peroxide;    Nitric oxide;   

DOI  :  10.1254/jjp.84.470

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)The effect of hydrogen peroxide (H2O2) on guinea pig nasal mucosa vasculature was studied by in vitro assay. H2O2 elicited relaxation of guinea pig nasal mucosa strips precontracted with phenylephrine in a concentration-dependent manner. The relaxant response to H2O2 was abolished in the presence of catalase. Preincubation of the strips with NG-nitro-L-arginine methyl ester or methylene blue significantly attenuated the relaxant responses elicited by H2O2. Fluorescence caused by DAF-2 DA, a fluorescence indicator for nitric oxide, was observed along the nasal mucosa vasculature in response to H2O2. These results suggest that H2O2 induced relaxation of the guinea pig nasal mucosa vasculature and that this relaxation in mediated by the NO/cGMP pathway.

【 授权许可】

Unknown