Involvement of Complexin II in Synaptic Plasticity in the CA1 Region of the Hippocampus:The Use of Complexin II-Lacking Mice

The Japanese Journal of Pharmacology

Takeshi Yagi²  Hisamitsu Ujihara³  Guang-Zhe Huang³  Sei-ichi Takahashi⁴  Hideto Kaba⁴  Shinpei Inoue¹ 

[1] CREST,Japan Science & Technology Corporation;Laboratory of Neurobiology,National Institute for Physiological Sciences,Myodaiji,Okazaki,Aichi 444-8585,Japan;Departments of Neuropsychiatry Kochi Medical School,Nankoku,Kochi 783-8505,Japan;Department of Physiology,Kochi Medical School,Nankoku,Kochi 783-8505,Japan

关键词: Complexin II-lacking mice;    Long-term potentiation;    Hippocampus;    CA1 pyramidal cell;    Whole-cell recording;   

DOI  :  10.1254/jjp.84.179

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(26)Cited-By(11)An electrophysiological study was performed with mice lacking complexin II, a presynaptic protein.The long−term potentiation(LTP)by high−frequency stimulation, recorded in the hippocampal CA1 area, was decreased in complexin II−lacking mice(CPXII KO mice).The overall postsynaptic currents elicited by low frequency stimulation on the Schaffer collateral/commissural fibers in the hippocampal CA1 pyramidal cells were not different between wild−type and mutant mice.Excitatory postsynaptic currents(EPSCs)recorded in the presence of 50μM bicuculline and inhibitory postsynaptic currents(IPSCs)recorded in the presence of 50μM AP−5(DL−2−amino−5−phosphonopentanoic acid)+ 30μM CNQX(6−cyano−7−nitroquinoxaline−2, 3−dione)were also identical between wild−types and mutants.Furthermore, the EPSCs following repetitive stimulation(10 Hz)in CPXII KO mice did not show any difference with wild−types.These findings suggest that complexin II does not play a crucial role in ordinary neural transmission, short−term synaptic plasticity or synaptic transmission during high−frequency repetitive stimulation.Therefore, the protein is thought to be involved in the LTP process following tetanic stimulation, including the induction and /or maintenance of the LTP.

【 授权许可】

Unknown