Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats

The Japanese Journal of Pharmacology

Shigenori Watanabe¹  Takao Shimazoe¹  Akiko Yoshimatsu¹  Atsuko Kawashimo¹ 

[1] Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University 62,Fukuoka 812-8582,Japan

关键词: Methamphetamine;    Adenosine;    Adenosine A1 receptor;   

DOI  :  10.1254/jjp.84.78

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(1)Adenosine was intraperitoneally(i.p.)injected to Wistar rats every 3 days with a total of 5 administrations.After a 7−day withdrawal, the animals were challengedwith methamphetamine(0.5 mg/kg, i.p.).The effect of methamphetamine on locomotor activity was significantly potentiated by repeated adenosine pre−treatment.Moreover, methamphetamine−induced dopamine release was also increased in the striatum.Methamphetamine−induced hyperactivity and dopamine release were significantly potentiated by repeated pre−treatment of an adenosine A1 agonist, N6−cyclohexyladenosine(0.5 mg/kg, i.p.).These results suggest that the acute effect of methamphetamine is potentiated by repeated pre−treatment of adenosine via adenosine A1 receptors.

【 授权许可】

Unknown