Roles of Prostanoids Revealed From Studies Using Mice Lacking Specific Prostanoid Receptors

The Japanese Journal of Pharmacology

Atsushi Ichikawa¹  Yukihiko Sugimoto²  Shuh Narumiya¹  Fumitaka Ushikubi² 

[1]Department of Physiological Chemistry,Faculty of Pharmaceutical Sciences,Kyoto University,Sakyo-ku,Kyoto 606-8315,Japan

[2]Department of Pharmacology,Asahikawa Medical College,Midorigaoka-Higashi 2-1-1-1,Asahikawa 078-8510,Japan

关键词: Prostanoid;    Prostaglandin;    Thromboxane;    Prostanoid receptor;    Knock-out mouse;   

DOI  :  10.1254/jjp.83.279

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(61)Cited-By(42)The actions of prostanoids in various physiological and pathophysiological conditions have been being examined using mice lacking different prostanoid receptors.Prostaglandin(PG)I2 worked not only as a mediator of inflammation but also as an antithrombotic agent.PGF2α was found to be an essential inducer of labor.Several important actions of PGE2 are exerted via each of the four PGE2 receptor subtypes:EP1, EP2, EP3 and EP4.PGE2 participated in colon carcinogenesis via the EP1.PGE2 also participates in ovulation and fertilization and contributes to the control of blood pressure under high−salt intake via the EP2.PGE2 worked as a mediator of febrile responses to both endogenous and exogenous pyrogens and as a regulator of bicarbonate secretion induced by acid−stimulation in the duodenum via the EP3.It regulated the closure of ductus arteriosus and showed bone resorbing action via the EP4.PGD2 was found to be a mediator of allergic asthma.These studies have revealed important roles of prostanoids, some of which had not previously been known.

【 授权许可】

Unknown