Bone Anabolic Effects of PTH(1-34)and Salmon Calcitonin in Ovariectomy- and Ovariectomy-Steroid-Induced Osteopenic Rats:A Histomorphometric and Biomechanical Study

The Japanese Journal of Pharmacology

Takaya Nitta¹  Tohru Fukushima¹  Hiroshi Furuichi¹  Tohru Fukuyama¹  Hiromichi Nakamuta¹  Masao Koida¹  Nobuo Izumo¹ 

[1]Department of Pharmacology,Faculty of Pharmaceutical Sciences,Setsunan University,Nagaotohge-cho 45-1,Hirakata,Osaka 573-0101,Japan

关键词: PTH(1-34);    Bone anabolic effect;    Calcitonin;    Steroid-induced osteopenia;   

DOI  :  10.1254/jjp.82.240

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(24)Cited-By(6)Using an experimental model of type 1 osteoporosis under the chronic therapy with an anti-inflammatory steroid, the bone anabolic effect of PTH(1-34)was evaluated by histomorphometrical and biomechanical analysis.Wistar female rats(12-week-old)were ovariectomized and allowed to develop an osteopenic model in the presence or absence of methylprednisolone acetate(MPA:0.1mg/kg, s.c., 3-days-a-week basis from the 5th week after ovariectomy(OVX)).The osteopenia that developed for the first 12 weeks after OVX was almost completely normalized by subsequent PTH pulsing(20μg/kg, s.c., 5-days-a-week)for 8 weeks starting at the 13th week;the following characteristics were observed:1)proximal tibial metaphysis:recovered bone volume, rather increased trabecular thickness and osteoid volume, and normalized eroded surface;2)5th lumbar vertebra(L-5):partially recovered trabecullar connectivity;3)femur and 4th lumbar vertebra(L-4):recovered mechanical strength in maximum elastic load and maximum elastic energy.The anabolic effect of PTH(1-34)was not substantially modified by MPA.Salmon calcitonin(SCT:10U/kg per day, s.c., 5-days-a-week, for 8 weeks)was anabolic in limited parameters:decreased number of osteoclasts, recovered maximum elastic load in femur, and partially recovered maximum elastic load in L-4.The results suggest that PTH(1-34)pulsing is able to recover OVX-induced osteopenia in the structure and mechanical strength not only of the cancellous bone but also of the cortical bone, and the anabolic effect can be clinically expected even under steroid medication.

【 授权许可】

Unknown