Involvement of Nitric Oxide From Nerves on Diarrhea Induced by Castor Oil in Rats

The Japanese Journal of Pharmacology

Shigeru Yamato¹  Kei Matsueda¹  Yumi Kato²  Akira Muraoka¹  Masayuki Uchida²  Ryousuke Shoda¹ 

[1] International Medical Center,Internal Medicine,Division of Gastoroenterology,Toyama 1-21-1,Shinjuku-ku,Tokyo 162-8655,Japan;Meiji Institute of Health Science,Naruda 540,Odawara,Kanagawa 250-0862,Japan

关键词: Castor oil;    7-Nitroindazole;    Capsaicin-sensitive afferent nerve;   

DOI  :  10.1254/jjp.82.168

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(7)Nitric oxide(NO)is involved in the mechanism of castor oil-induced diarrhea.This study was performed to elucidate the source of NO.Diarrhea was induced by oral administration of castor oil in rats.Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole.This effect was attenuated by the treatment with L-arginine.Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea.NG-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats.These data suggest, a least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.

【 授权许可】

Unknown