Anti-type I Allergic Mechanisms of Mao-bushi-saishin-to in Mice

The Japanese Journal of Pharmacology

Yasuhiro Komatsu¹  Akira Iizuka¹  Eiichi Fujihira²  Yoshiki Ikeda¹  Atsushi Ishige¹  Sakae Amagaya¹ 

[1] Central Research Laboratories,Tsumura & Co.,3586,Yoshiwara,Ami-machi,Inashiki-gun,Ibaraki 300-1192,Japan;Department of Pharmacotherapy,Hokkaido College of Pharmacy,7-1,Katsuraoka-machi,Otaru,Hokkaido 047-0264,Japan

关键词: Mao-bushi-saishin-to;    Anti-allergy;    Interleukin-4;    IgE;    Spleen cell;   

DOI  :  10.1254/jjp.82.29

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(22)Cited-By(7)We investigated the anti−allergic effect of mao−bushi−saishin−to(MBS)on the type I allergy model in mice.When MBS was administered orally at a dose of 0.5 or 1.0g/kg, edema of the footpad, the amount of plasma IgE and the ratio of eosinophilic leukocytes in peritoneal exudate cells were all dose−relatedly suppressed.Moreover to investigate the anti−type I allergic mechanisms of MBS, enzyme−linked immunosorbent assay was performed to determine the interleukin(IL)−4, IL−5 and interferon(IFN)−gamma production from splenocytes that were stimulated by pokeweed mitogen for 48 h.In addition, we assayed IgE production from splenic B cells stimulated with the lipopolysaccharide and IL−4 for 7 days.MBS inhibited the IL−4 and IFN−gamma production, but IL−5 and IgE production were not affected.Thus possibly, the inhibition of IL−4 production may partially be involved in the expression of the anti−type I allergic effects of MBS.

【 授权许可】

Unknown