Effects of Activation of Renal Adenosine A2 Receptor on Renal Function and Renin Release in Dogs

The Japanese Journal of Pharmacology

Hiroshi Iwao²  Katsuyuki Miura²  Michiaki Okumura¹  Shinya Yamanaka²  Shokei Kim² 

[1] Department of Internal Medicine, Osaka City General Hospital;Department of Pharmacology, Osaka City University Medical School

关键词: Adenosine;    Adenosine A2 receptor;    Renal hemodynamics;   

DOI  :  10.1254/jjp.80.173

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(12)Cited-By(4)Direct effects of adenosine A2 receptor activation on renal function were examined in dogs. When renal perfusion pressure was maintained constant at 100 mmHg, renal administration of a selective A2 receptor agonist, CGS 21680C (sodium salt of CGS 21680, 2-[p-(2-carboxyethyl) phenethylamino]-5'-N-ethylcarboxamido adenosine) (1 μg·kg-1·min-1), although it decreased blood pressure by 20 mmHg, increased renal blood flow and renin release, whereas glomerular filtration rate and urine flow were unaffected. These results suggest that stimulation of renal A2 receptor led to both afferent and efferent arteriolar dilatation, whereas renal A2 receptor plays a minor role in urine formation. CGS 21680C induced renin release and tachycardia that were blocked by propranolol, indicating these effects of A2 receptor stimulation appeared to be indirect.

【 授权许可】

Unknown