Morphometric Evidence That YM175, a Bisphosphonate, Reduces Trabecular Bone Resorption in Ovariectomized Dogs With Dietary Calcium Restriction

The Japanese Journal of Pharmacology

Haruko Nishikawa¹  Hiroyuki Motoie¹  Naoto O’uchi¹  Hisataka Shikama¹ 

[1] Metabolic Diseases Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

关键词: Histomorphometry;    Bone resorption;    YM175;   

DOI  :  10.1254/jjp.79.397

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)We examined mechanisms by which incadronate disodium (YM175) prevented bone resorption in ovariectomized dogs with dietary calcium restriction using the morphometrical method. YM175 (0.01-1.0 mg/kg) was given to ovariectomized dogs for 18 months. Because lumbar bone mineral density remained constant at month 17, we assumed that the trabecular bone resorption rate was equal to the bone formation rate and that wall thickness equaled resorption cavity depth. YM175 decreased both the bone resorption rate per number of osteoclasts and resorption cavity depth of cancellous pockets which were increased in ovariectomized dogs. These results suggest that YM175 reduces bone loss by decreasing the resorbing activity of osteoclasts.

【 授权许可】

Unknown