ATP-Sensitive Potassium Channels Regulate In Vivo Dopamine Release in Rat Striatum

The Japanese Journal of Pharmacology

Dawn Xiao-Dong Zhu¹  Jorge D.¹  James P. Sullivan¹ 

[1] Neurological and Urological Diseases Research, Abbott Laboratories

关键词: Microdialysis;    Dopamine;    Amphetamine;    Cromakalim;    Glyburide;   

DOI  :  10.1254/jjp.79.59

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(25)Cited-By(7)ATP-sensitive K+ channels (KATP) are distributed in a variety of tissues including smooth muscle, cardiac and skeletal muscle, pancreatic β-cells and neurons. Since KATP channels are present in the nigrostriatal dopamine (DA) pathway, the effect of potassium-channel modulators on the release of DA in the striatum of conscious, freely-moving rats was investigated. The extracellular concentration of DA was significantly decreased by the KATP-channel opener (-)-cromakalim but not by diazoxide. (-)-Cromakalim was effective at 100 and 1000 μM concentrations, and the maximum decrease was 54% below baseline. d-Amphetamine significantly increased extracellular DA levels at the doses of 0.75 and 1.5 mg/kg, s.c. with a 770% maximum increase. (-)-Cromakalim had no effect on d-amphetamine-induced DA release, while glyburide, a KATP blocker, significantly potentiated the effects of a low dose of d-amphetamine. These data indicate that K+ channels present in the nigrostriatal dopaminergic terminals modulate basal release as well as evoked release of DA.

【 授权许可】

Unknown