Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory

The Japanese Journal of Pharmacology

Eishichi Miyamoto¹  Kohji Fukunaga¹ 

[1] Department of Pharmacology, Kumamoto University School of Medicine

关键词: Ca2+/calmodulin-dependent protein kinase II;    Long-term potentiation;    Long-term depression;    Hippocampus;    Spatial learining;   

DOI  :  10.1254/jjp.79.7

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(39)Cited-By(11)There have been recent advances in understanding the molecular basis of the long-term potentiatiion (LTP) of synaptic transmission in the hippocampus. This review documents current views on mechanisms underlying LTP induction, from activation of the NMDA receptor to stimulation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). We will focus in particular on recent findings of how CaM kinase II encodes the frequency of synaptic usage and serves as a molecular memory switch at the synapse. Furthermore, a role for CaM kinase II in spatial learning and memory is demonstrated by recent studies using transgenic mice.

【 授权许可】

Unknown