Decrease in Participation of Nitric Oxide in Nonadrenergic, Noncholinergic Relaxation of Rat Intestine With Age

The Japanese Journal of Pharmacology

Michiru Yamaji²  Koichi Takatsuji¹  Fumiaki Hata²  Yutaka Okishio²  Satomi Niioka²  Tadayoshi Takeuchi²  Hideaki Nishio²  Toshiaki Ishii² 

[1] Osaka Prefectural College of Nursing;Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University

关键词: Nitric oxide;    Nonadrenergic;    noncholinergic (NANC) relaxation;    Aging;    Rat intestine;    Nitric oxide synthase;   

DOI  :  10.1254/jjp.78.293

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(28)Cited-By(24)Participation of nitric oxide in the electrical field stimulation-induced nonadrenergic, noncholinergic (NANC) relaxation in various intestinal regions was studied in 2- to 50-week-old Wistar rats. In the jejunum of 2-week-old rats, the extent of the nitric oxide-mediated component of the relaxation of longitudinal muscle was approximately 60 - 70%, whereas the component was 40 - 50% in 4-week-old rats and was absent in 8- and 50-week-old rats. Thus, nitric oxide seems to be the most important mediator at young ages but its significance is lost with age. The same tendency as that in the jejunum was also shown in longitudinal muscle of the ileum, proximal and distal colon, and rectum. The tendency was also shown in the circular muscle of the rectum. Sensitivity of the longitudinal muscle of the jejunum and proximal colon to exogenously added nitric oxide was high in younger rats. Immunoreactive structures for nitric oxide synthase were observed in the circular muscle layer of the rectum. The population of the structures was denser in 4-week-old than that in 50-week-old. The results suggest that NANC relaxation in every region of the intestine at 2-week-old is almost solely mediated by nitric oxide, and its significance as an inhibitory mediator gradually or rapidly decreases with age.

【 授权许可】

Unknown