Salivary Amylase Activity of Rats Fed a Low Calcium Diet

The Japanese Journal of Pharmacology

Shigeki Sakata¹  Makoto Okamura¹  Mitsuko Shinohara¹  Kiyoshi Ohura¹  Pao-Li Wang¹  Noboru Murakawa¹  Masaki Endo¹  Michiharu Daito²  Shinya Shirasu² 

[1] Department of Pharmacology, Osaka Dental University;Department of Pediatric Dentistry, Osaka Dental University

关键词: Saliva;    Amylase;    Low Ca diet;    Parotid gland;    Cyclic AMP;   

DOI  :  10.1254/jjp.78.279

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)Cited-By(4)Wistar strain rats fed low calcium diets (1, 2, 3, 4, 6 and 8 weeks) exhibited changes in secretory function of whole saliva. In particular, there were changes in salivary flow rate, total salivary protein, amylase enzyme activity, salivary amylase content and the level of cyclic AMP in the parotid gland acinar cell. Although there were no changes for the first 3 weeks, the levels increased at week 4 and decreased at week 6. The wet weight of the parotid gland started to decrease at week 4. These results suggest that when fed low calcium diets for long periods of time, rats develop defective salivary secretion.

【 授权许可】

Unknown