Involvement of N-Type Voltage-Activated Ca2+ Channels in the Release of Endogenous Noradrenaline from the Isolated Vascularly Perfused Rat Stomach

The Japanese Journal of Pharmacology

Yoshitsugu Osumi¹  Yasunobu Okuma¹  Kunihiko Yokotani¹ 

[1] Department of Pharmacology, Kochi Medical School

关键词: Noradrenaline release;    Rat stomach;    N-type Ca2+ channel;   

DOI  :  10.1254/jjp.78.75

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(7)We characterized the voltage-activated Ca2+ channels involved in noradrenaline (NA) release from gastric sympathetic neurons using isolated, vascularly perfused rat stomach. The evoked NA release by electrical stimulation of periarterial nerves was abolished by calcium removal from the perfusion medium and by cadmium. ω-Conotoxin GVIA (N-type Ca2+-channel blocker) effectively and ω-conotoxin MVIIC (N/P/Q-type blocker) slightly inhibited the evoked NA, while ω-agatoxin IVA (P-type blocker) had no effect. These results suggest that ω-conotoxin GVIA and ω-conotoxin MVIIC-sensitive N-type Ca2+ channels are involved in NA release from the rat gastric sympathetic nerve terminals.

【 授权许可】

Unknown