Pharmacological Studies on the Novel Antiallergic Drug HQL-79: I. Antiallergic and Antiasthmatic Effects in Various Experimental Models

The Japanese Journal of Pharmacology

Ichiro Hirotsu¹  Kosuke Aritake¹  Tadato Tani¹  Masanori Hizue¹  Kumi Hayashi¹  Yoshiyuki Kimura¹  Nobutoshi Matsushita²  Masatoshi Hayashi¹  Hiromichi Nakajima¹  Kazuhiko Mitsui¹  Ayumi Takada¹ 

[1] New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitomo Metal Industries, Ltd.;Present address for correspondence: Pharmacological Research Group, Bioclinical Research Division, Rohto Pharmaceutical Co., Ltd.

关键词: Antiallergic drug;    Late asthmatic response;    Airway inflammation;    Delayed-type hypersensitivity;    HQL-79;   

DOI  :  10.1254/jjp.78.1

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(30)Cited-By(11)The effects of oral administration of 4-benzhydryloxy-1-{3-(1H-tetrazol-5-yl)-propyl}piperidine (HQL-79), a newly synthesized antiallergic drug, in various experimental allergic and asthmatic models were investigated. HQL-79 markedly inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis in rats, antigen-induced bronchoconstriction and nasal vascular permeability in actively sensitized guinea pigs, like epinastine and ketotifen did. Airway eosinophilia in repeatedly antigen-exposed guinea pigs was suppressed by chronic administration of HQL-79 for 2 weeks. In another experiment, the antigen-induced late asthmatic response (LAR) in metyrapone-treated guinea pigs was also ameliorated by chronic treatment with HQL-79. Moreover, HQL-79 partially inhibited the toluene diisocyanate-induced delayed-type hypersensitivity (DTH) reaction in mice when administered chronically during the immunization period. The corticosteroid dexamethasone inhibited the airway inflammatory responses in guinea pigs and the DTH in mice. These results indicate that HQL-79 has potent inhibitory effects on the immediate hypersensitivity reactions, and when administered chronically, it also inhibits airway eosinophilia, LAR and DTH, similarly to corticosteroids.

【 授权许可】

Unknown